What will you do:
In this laboratory-based role, you will leverage your scientific expertise in genome engineering and innovative thinking to develop novel tools and applications that can lead to breakthrough therapies. As a key member of cross-functional project teams, you will develop and evaluate genome editing strategies for specific disease projects. Accountabilities will include innovative optimization of genome engineering technologies to facilitate effective gene editing in target cell & tissue types, developing relevant assays, analyzing gene editing outcomes, documenting, interpreting, and communicating results to appropriate partners.
Your accountabilities will include:
• Establishing and maintaining disease cell models using immortalized or iPSC cell lines
• Establishing and running cellular and biochemical assays to evaluate efficacy of therapeutic genome editing approaches in disease models
• Documenting, interpreting and communicating results to stakeholders and partners
Essential for the role:
• PhD degree in molecular cell biology or relevant areas with strong wet-lab skills, or MSc degree with equivalent experience
• Experience with handling and differentiating iPSCs to different cell types (e.g. liver, heart)
• Track record of establishing high-quality cellular assays (e.g. viability, metabolic activity, protein quantification, flow cytometry, microscopy)
• Strong communication skills, scientific rigor and ethics, ability to effectively work independently and collaboratively in a team
Desirable for the role:
• Experience in metabolism research
• Understanding and previous hands-on experience with CRISPR-Cas9 technologies
• Hands-on experience with standard molecular biology approaches for quantifying protein levels (e.g. Western blot, ELISA) or measuring protein activity
• Experience working with lentiviral vectors for engineering cell models
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